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Dextran Sulfate Sodium Salt MP Grade (36,000-50,000 Da):

Cat. No Pack Size Availability Price (USD)
0216011010 10 g 0.00
0216011025 25 g 0.00
0216011050 50 g 0.00
0216011080 100 g 0.00
0216011090 500 g 0.00
MP Premium DSS - The World's Most Potent Intestinal Inflammation Reagent
Dextran Sulfate Sodium Salt (DSS) is a polyanionic derivative of Dextran. MP Premium DSS is offered at the highest quality, purity and reproducible form which enable it for multiple applications in clinical, molecular biology, biomedical and possibly for cosmetic applications.
MP Premium Dextran Sulfate Sodium Salt has the following properties:
Inflammatory Bowel Disease (IBD) is characterized by chronic and relapsing inflammation of the gastrointestinal tract which is associated with increased risk of developing colitis-associated cancer. Several animal models have been used to study colitis and one such model involves the oral administration of dextran sulfate sodium salt (DSS) in the drinking water of mice leading to chronic colitis. This DSS induced colitis model is spontaneous and is used to assess the therapeutic potential of treatments for IBD.
Accelerate your IBD research with the most validated and attested Dextran Sulfate Sodium Salt. Our MP Premium DSS is well characterized and offers the following advantages:
Bamba et al (2012) performed a comparative analysis of 3 different DSS preparations to examine the chemical and cytotoxic properties as well as severity of colitis. Their study concluded that the DSS from MP Biomedicals induced a severe colitis as indicated by body weight transition, DAI score, colon weight/length and histological scores.

Bamba, S. et al (2012) Digestive Diseases and Sciences, 57 (2), pp. 327-334.



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Table 1. Dosage of DSS for different strains of mice
Strain Dose (days) Reference
C57BL/6 2.5% (8) 1
Wild-type C57BL/6J(m) 3% (6) 2
C57BL/6 AhR null, WT 3.5% (7) 3
C57BL/6 5% (7) 4
C57BL/6 1.5% (7) 5
Balb/c 1% (10) 6
Balb/c 3% (5) 7
BALB/c 1-5% (10) 8
BALB/c; NMRI/KI 2.5-5% 9
IL-5-/- and +/+ 2.9%, 5% (9) 10
Balb/c; athymic nu/nu CD-1 (BR) 5% (7-35) 11
WT; CCR9(-/-); CCL25 (-/-) 2% (7) 12
Wild-type; DPIV -/- 2% (6) 13
C57BL//6 5% (7) 14

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8. T.Rochat, L.Bermudez-Humaran, J-J Gratadoux et al., Anti-infammatory efects of Lactobacillus casei BL23 producing or not a manganese-dependent catalase on DSS-induced colitis in mice, Microb. CellFact., 2007; 20(6), 22.

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Table 2. Dosage of DSS for different strains of rats
Strain Dose (days) Reference
Wistar 2% (2 weeks â€" 6 months) 15
Sprague-Dawley 5% (9) 16, 17, 18
Sprague-Dawley 5% (6) 19
Sprague-Dawley 5% (7) 20
Wistar 2.5% (7) 21
Wistar 5% (10) 22
Wistar 2-4% (7) 23
ACI 5% (14) 24

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17. J.Dicksved, O.Schreiber, B.Willing, et al., Lactobacillus reuteri maintains a functional mucosal barrier during DSS treatment despite mucus layer dysfunction. PLoS One, 2012;7(9):e46399.

18. J.Petersson, O.Schreiber, A.Steege et al., eNOS involved incolitis-induced mucosal blood flow increase, Am.J.Physiol.Gastrointest.Liver, 2007; 293, G1281-1287.

19. V.Vasina, M.Broccoli, M.G.Ursino et al., Non-peptidyl low molecular weight radical scavenger IAC attenuates DSS-induced colitis in rats. World J.Gastroenterol., 2010; 16(29), 3642-50.

20. X.Z.Shi, J.H.Winston and S.K.Sarna, Differential immune and genetic responses in rat models of Chrohn´s colitis and ulcerative colitis, Am.J.Physiol.Gastrointest.Liver Physiol., 2011; 300(1), G41-51.

21. I.Hirono, K.Kuhara, S.Hosaka et al., Induction of intestinal tumors in rats by dextran sulfate sodium. J.Natl.Cancer Inst, 1981;66(3)579-583.

22. R.Lopez-Posadeas, P.Requena, R.Gonzalez et al., Bovine glucomacropeptide has intestinal anti-in_ammatory e_ects in rats with dextran-sulfate induced colitis, J.Nutr., 2010; 140(11), 2014-2019.

23. T.Shimizu, M.Suzuki, J.Fujimura et al., The relationship between the concentration of dextran sodium sulfate and the degree of induced experimental colitis in weanling rats, J.Pediatric Gastro. Nutrition, 2003;37, 481-486.

24. I.Hirono, K.Kuhara, S.Hosaka et al., Induction of intestinal tumors in rats by dextran sulfate sodium. J.Natl.Cancer Inst, 1981;66(3)579-483.


Table 3. Dosage of DSS for other animals
Strain Dose (days) Reference
Hamster 2.5%(6) 25
Hamster 1% 26, 17, 18
Guinea Pig 3% (4) 27
Pig (Yorkshire) 1.25 g/kg BW(5) 28

25. A.Karlsson, A.Jägervall, M.Pettersson et al., Dextran sulphate sodium induces acute colitis and alters hepatic function in hamsters, Int. Immunopharmacol., 2008;8(1),20-27.

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27. T.Iwanaga, O.Hoshi, H.Han et al., Morphological analysis of acute ulcerous colitis experimentally induced by dextran sulfate sodium in the guinea pig, J. Gastroenterol., 1994;430-438.

28. D.Young, M.Ibuki, T.Nakamori et al., Soy-derived di-and tripeptides alleviate colon and ileum inflammation in pigs with dextran sodium sulfate-induced colitis, J.Nutr., 2012;142(2), 363-8.